Highlights
•Transmembrane helix of death receptor 5 oligomerizes to drive downstream signaling
•The transmembrane helix in lipid bilayer forms dimer-trimer interaction network
•Receptor ectodomain in pre-ligand state inhibits receptor clustering and activation
• Ligand binding overcomes the pre-ligand autoinhibition

Highlights
• ER exit sites are endowed with an auto-regulatory signaling complex called AREX
•The COPII subunit Sec24 senses folded cargo and activates the AREX signaling network
•AREX responds to folded cargo fluxes by regulating cargo export and protein synthesis
•AREX maintains potentially harmful folded cargo in the ER at steady low levels

Highlights
• Acetylation suppresses cGAS activity
• Aspirin directly acetylates cGAS
• Aspirin inhibits cGAS-mediated interferon production
• Aspirin alleviates DNA-induced autoimmunity in AGS mouse models and patient cells